Dr Anthony Redmond

Current position: Post-doctoral research fellow: University of Dublin, Trinity College (with Aoife McLysaght, Molecular Evolution Lab)

 

PhD project: Phylogenomics to reconstruct the origins and evolution of immunity (Viva date: Oct 2017)

Postgraduate research

My PhD project was focussed on the application of phylogenomic approaches to understand the origins and evolution of immunity. Rampant gene loss events as well as rapid evolutionary rates have confounded research into the evolution of immune pathways. The goal of my project was to pair newly available genomic data at key poorly explored nodes in the animal (e.g. sponges and comb jellies) and vertebrate (e.g. sharks and lampreys) tree of life, with state-of-the-art phylogenetic methods, including for placing the tree root, that minimize artefacts in immune gene phylogenies and more accurately reconstruct evolutionary history.

Publications while in Macqueen Lab:​

Redmond AK, Macqueen DJ, Dooley H. 2018. Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets. BMC Evol. Biol. 18: 169

 

Pettinello R, Redmond AK, Secombes CJ, Macqueen DJ, Dooley H. 2017. Evolutionary history of the T cell receptor complex as revealed by small-spotted catshark (Scyliorhinus canicula). Dev Comp Immunol. 74:125-135.

Redmond AK, Pettinello, R, Dooley, H. 2017. Outgroup, alignment and modelling improvements indicate that two TNFSF13-like genes existed in the vertebrate ancestor. Immunogenetics. 69:187-192

Robertson FM, Gundappa MK, Grammes F, Hvidsten TR, Redmond AK, Lien, S. Martin SAM, Holland PW, Sandve SR, Macqueen DJ. 2017. Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification. Genome Biol. In press


Zou J, Redmond AK, Qi Z, Dooley H, Secombes CJ. 2015. The CXC chemokine receptors of fish: insights into CXCR evolution in the vertebrates. Gen Comp Endocrinol. 215:117-31


Li R, Redmond AK, Wang T, Bird S, Dooley H, Secombes, CJ., 2015. Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula). Fish Shellfish Immunol. 47 :381-9.

From: Redmond AK, Pettinello, R, Dooley, H. 2017. Outgroup, alignment and modelling improvements indicate that two TNFSF13-like genes existed in the vertebrate ancestor. Immunogenetics. 69:187-192