Genome Biology and Evolution | macqueen-lab-group

Genome Biology & Evolution

We combine genome sequencing, comparative genomics, phylogenetics and gene expression profiling to explore the role of whole genome duplication in eukaryotic evolution, reconstruct the evolution of gene families, and infer processes of genome and physiological evolution across the tree of life, with a particular focus on aquatic creatures

Representative recent papers:

Liu S, Shi C, Chen C, Tan Y, Tian Y, Macqueen DJ, Li Q. 2025. Haplotype-resolved genomes provide insights into the origins and functional significance of genome diversity in bivalves. Cell Rep. 44:115697. doi: 10.1016/j.celrep.2025.115697.

Taylor RS, Ruiz Daniels R, Macqueen DJ. 2025. Cell type resolved expression of duplicate genes retained from whole genome duplication in Atlantic salmon. Genome Biol. Evol. evaf076. doi: 10.1093/gbe/evaf076.

Redmond AK, Casey D, Gundappa MK, Macqueen DJ, McLysaght A. 2023. Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor. Nat Commun. 14: 2879. doi: 10.1038/s41467-023-38714-z.

Matz H, Taylor RS, Redmond AK, Hill TM, Ruiz Daniels R, Beltran M, Henderson NC, Macqueen DJ, Dooley H. 2023. Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers. Cell Reports. 42: 112664

Gundappa MK, To TH, Grønvold L, Martin SAM, Lien S, Geist, J, Hazlerigg D, Sandve SR, Macqueen DJ. 2022.Genome-wide reconstruction of rediploidization following autopolyploidization across one hundred million years of salmonid evolution. Mol Biol Evol. msab310. doi:10.1093/molbev/msab310