Genome Biology & Evolution 

We are combining genome sequencing, comparative genomics, phylogenetics and gene expression profiling to explore the role of genome duplication in fish evolution, to reconstruct the evolution of gene families of interest, and to infer patterns of lineage diversification.  

Lab Members:
Dr Simen Sandve & Prof. Sigbjorn Lien (CIGENE, Norwegian University of Life Sciences)
Prof. Peter Holland (University of Oxford)
Prof. David Hazlerigg (University of Tromsø)
Representative papers:
Redmond AK, Ohta Y, Criscitiello MF, Macqueen DJ, Flajnik MF, Dooley M. Haptoglobin is a divergent MASP family member that neofunctionalized to recycle hemoglobin via CD163 in mammals. J. Immunol. pii: ji1800508.
Robertson FM, Gundappa MK, Grammes F, Hvidsten TR, Redmond AK, Lien, S. Martin SAM, Holland PW, Sandve SR, Macqueen DJ. 2017. Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification. Genome Biol. 18:111. DOI: 10.1186/s13059-017-1241-z
Gubry-Rangin C, Kratsch C, Williams TA, McHardy AC, Embley TM, Prosser JI, Macqueen DJ. 2015. Coupling of diversification and pH adaptation during the evolution of terrestrial Thaumarchaeota. Proc. Natl. Acad. Sci. USA. 30:  9370–9375. DOI10.1073/pnas.1419329112
Macqueen DJ, Johnston, IA. 2014. A well-constrained estimate for the timing of the salmonid whole genome duplication reveals major decoupling from species diversification. Proc. Soc. Biol. B. 281: 20132881. DOI: 10.1098/rspb.2013.2881
From Redmond et al. Clock rooting reveals that complement-like immunity existed in the first animals. In Prep.