Fish health and physiology

The group has long-standing interests in fish physiology and health, with a focus on systems that regulate growth and immunity. We are characterising these systems at the molecular and cellular level, with a focus on understanding regulation of gene expression. We are currently using single cell genomics to resolve the cell-specific basis for fish health traits.

Representative papers:

Taylor RT,  Daniels RR,   Dobie R, Naseer S, Clark T, Henderson N,  Boudinot P,  Martin SA, Macqueen DJ. 2022. Single cell transcriptomics of Atlantic salmon (Salmo salar L.) liver reveals cellular heterogeneity and immunological responses to challenge by Aeromonas salmonicida. Front. Immunol. doi: 10.3389/fimmu.2022.984799

 

Bakke FK, Monte M, Stead DA, Cornulier T, Causey DR, Douglas A, Macqueen DJ*, Dooley H*. 2020. Plasma proteome responses in salmonid fish following immunization. Front. Immunol. doi: 10.3389/fimmu.2020.581070 * Joint corresponding and senior author 

Causey DR, Kim JH, Devlin RH, Martin SAM, Macqueen DJ. 2019. The AMPK system of salmonid fishes was expanded through genome duplication and is regulated by growth and immune status in muscle. Sci. Rep. 9: 9819
 
Causey DR, Potz M, Stead DA, Secombes CJ, Macqueen DJ. 2018. High-throughput proteomic expression profiling of the fish liver response to bacterial challenge. BMC Genomics. 19: 719

Causey DR, Kim JH, Stead DA, Devlin RH, Martin SAM, Macqueen DJ. 2018. Proteomic comparison of selective breeding and growth hormone transgenesis in fish: Unique pathways to enhanced growth J. Proteomics. pii: S1874-3919(18)30325-7.
 
Fig. 1.png
From Causey et al. 2018. High-throughput proteomic expression profiling of the fish liver response to bacterial challenge. BMC Genomics. 19: 719.